1 清华大学生物医学工程系, 北京 100086
2 清华大学电子工程系, 北京 100086
光声计算断层成像是近年发展起来的一种非入侵式和非电离式的新型生物医学成像方法,其临床应用对成像精度要求较高。生物组织内声速分布的不均匀性时常造成重建的光声图像中存在较为严重的伪影。实现光声IP和声速分布的联合重建是改善成像效果、去除成像伪影的重要途径之一,也是仅通过光声单一模态的信息获取就可以获得多模态信息(包括光学和声学信息)的崭新途径。总结了几种本研究组近年来开发的光声-声速联合重建方法,包括基于特征耦合、基于波前整形以及基于信号互补的方法。同时,分析了这几种方法的优劣势和适用场景,以期帮助人们更好地利用这些方法解决光声图像质量提高和多模态图像获取的问题。
医用光学 光声成像 医学影像 声速矫正 声速断层成像 多模态成像 中国激光
2021, 48(15): 1507001
Author Affiliations
Abstract
1 Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
2 Center for Biomedical Imaging Research, Tsinghua University, Beijing 100084, China
A reconstruction method guided by early-photon fluorescence yield tomography is proposed for time-domain fluorescence lifetime tomography (FLT) in this study. The method employs the early-arriving photons to reconstruct a fluorescence yield map, which is utilized as a priori information to reconstruct the FLT via all the photons along the temporal-point spread functions. Phantom experiments demonstrate that, compared with the method using all the photons for reconstruction of fluorescence yield and lifetime maps, the proposed method can achieve higher spatial resolution and reduced crosstalk between different targets without sacrificing the quantification accuracy of lifetime and contrast between heterogeneous targets.
170.3880 Medical and biological imaging 170.3010 Image reconstruction techniques 170.6960 Tomography 170.6920 Time-resolved imaging Chinese Optics Letters
2016, 14(7): 071702
